We introduce a framework for analyzing symmetry of 3D anatomical structures using elastic deformations of their boundaries (surfaces). The basic idea is to define a space of parameterized surfaces and to compute geodesic paths between the objects and their arbitrary reflections using a Riemannian structure. Elastic matching, based on opti- mal (non-linear) re-parameterizations (grid deformations) of surfaces, provides a better registration of points across shapes, as compared to the commonly-used linear regis- trations. A crucial step of orientation alignment, akin to finding planes of symmetry, is performed as a search for shortest geodesic paths. This framework is fully automatic and provides a measure of symmetry, the nearest symmet- ric shape and the optimal deformation to make an object symmetric. We demonstrate this framework through multi- ple toy examples on simple and complicated surfaces. We also explore the use of symmetry analysis in differentiating between healthy and subjects with Attention Deficit Hyper- activity Disorder.